Genome-Wide Association Studies of Hypertension : Light at the End of the Tunnel
Joint Authors
Hastie, Claire E.
Padmanabhan, Sandosh
Dominiczak, Anna F.
Source
International Journal of Hypertension
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Despite its significant genetic component, the study of hypertension by genome-wide association presents more challenges than other common complex diseases.
Its high prevalence, heterogeneity, and somewhat unclear definition are the challenges that need to be overcome on one hand.
On the other hand, there are issues of small effect sizes and pleiotropism that are not specific to hypertension alone but nonetheless magnify the problems of genetic dissection when coupled with phenotypic misclassification.
We discuss issues of study design and summarise published genome-wide association studies (GWASs) of hypertension and blood pressure.
With careful study design and analysis success is possible, as demonstrated by the recent large-scale studies.
Following these, there is still further scope to advance the field through high fidelity phenotyping and deep sequencing.
American Psychological Association (APA)
Hastie, Claire E.& Padmanabhan, Sandosh& Dominiczak, Anna F.. 2010. Genome-Wide Association Studies of Hypertension : Light at the End of the Tunnel. International Journal of Hypertension،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-477334
Modern Language Association (MLA)
Hastie, Claire E.…[et al.]. Genome-Wide Association Studies of Hypertension : Light at the End of the Tunnel. International Journal of Hypertension No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-477334
American Medical Association (AMA)
Hastie, Claire E.& Padmanabhan, Sandosh& Dominiczak, Anna F.. Genome-Wide Association Studies of Hypertension : Light at the End of the Tunnel. International Journal of Hypertension. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-477334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477334