Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer’s Disease
Joint Authors
Li, Jin-Ping
Zhang, Gan-lin
Wang, Xiao-min
Zhang, Xiao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia, characterized by progressive loss of memory and cognitive dysfunctions.
A central pathological event of AD is accumulation and deposition of cytotoxic amyloid-β peptide (Aβ) in the brain parenchyma.
Heparan sulfate proteoglycans (HSPGs) and the side chains heparan sulfate (HS) are found associated with Aβ deposits in the brains of AD patients and transgenic animal models of AD.
A growing body of evidence from in vitro and in vivo studies suggests functional roles of HSPG/HS in Aβ pathogenesis.
Although the question of “how and why HSPG/HS is codeposited with Aβ?” still remains, it is within reach to understand the mechanisms of the events.
Recent progress by immunohistochemical examination with advanced antibodies shed light on molecular structures of HS codeposited with Aβ.
Several recent reports have provided important new insights into the roles of HSPG in Aβ pathogenesis.
Particularly, experiments on mouse models revealed indispensible functions of HSPG in modulating Aβ-associated neuroinflammation and clearance of Aβ from the brain.
Application of molecules to interfere with the interaction between HS and Aβ peptides has demonstrated beneficial effects on AD mouse models.
Elucidating the functions of HSPG/HS in Aβ deposition and toxicity is leading to further understanding of the complex pathology of AD.
The progress is encouraging development of new treatments for AD by targeting HS-Aβ interactions.
American Psychological Association (APA)
Zhang, Gan-lin& Zhang, Xiao& Wang, Xiao-min& Li, Jin-Ping. 2014. Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477841
Modern Language Association (MLA)
Zhang, Gan-lin…[et al.]. Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer’s Disease. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-477841
American Medical Association (AMA)
Zhang, Gan-lin& Zhang, Xiao& Wang, Xiao-min& Li, Jin-Ping. Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477841