Antileishmanial Activity of Warifteine : A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae)
Joint Authors
Figueiredo, Regina Célia Bressan Queiroz
da Silva, Eliete Cavalcanti
Fernandes Marinho, Alexsandro
Piuvezan, Márcia Regina
Pimentel Cassilhas, Ana Paula
Medeiros, Paloma Lys de
Paes de Andrade, Paulo
Dias Rayol, Cynthia
Brabosa-Filho, José Maria
Militão, Gardenia Carmen Gadelha
da Silva, Teresinha Gonçalves
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Leishmania (L.) chagasi is the etiological agent of visceral leishmaniasis, an important endemic zoonosis in the American continent, as well as in many other countries in Asia, Africa, and Mediterranean Europe.
The treatment is difficult due to the high toxicity of the available drugs, high costs, and emergence of resistance in the parasites.
Therefore, there is an urgent need for new leishmanicidal agents.
The bisbenzylisoquinoline alkaloids have been related to antibacterial, antiprotozoal, and antifungal activities.
The aim of this study was to evaluate the growth inhibitory activity of warifteine (bisbenzylisoquinoline alkaloid) against L.
chagasi promastigotes in axenic cultures and the occurrence of drug-induced ultrastructural changes in the parasite.
This bisbenzylisoquinoline alkaloid was isolated from the leaves and roots of Cissampelos sympodialis Eichl.
(Menispermaceae), a plant commonly used for the treatment of various diseases in Brazilian folk medicine.
Using the purified warifteine, the 50% inhibitory concentration (IC50) was determined at 0.08 mg/mL after 72 h in culture, inducing significant changes in the parasite morphology, like aberrant multisepted forms and blebs in the plasma membrane.
In conclusion, warifteine represents an attractive candidate for future pharmacological studies aiming new leishmanicidal drugs.
American Psychological Association (APA)
da Silva, Eliete Cavalcanti& Dias Rayol, Cynthia& Medeiros, Paloma Lys de& Figueiredo, Regina Célia Bressan Queiroz& Piuvezan, Márcia Regina& Brabosa-Filho, José Maria…[et al.]. 2012. Antileishmanial Activity of Warifteine : A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae). The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-477880
Modern Language Association (MLA)
da Silva, Eliete Cavalcanti…[et al.]. Antileishmanial Activity of Warifteine : A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae). The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-477880
American Medical Association (AMA)
da Silva, Eliete Cavalcanti& Dias Rayol, Cynthia& Medeiros, Paloma Lys de& Figueiredo, Regina Célia Bressan Queiroz& Piuvezan, Márcia Regina& Brabosa-Filho, José Maria…[et al.]. Antileishmanial Activity of Warifteine : A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae). The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-477880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477880