Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production

Joint Authors

Chiuso-Minicucci, Fernanda
Ishikawa, Larissa Lumi Watanabe
Zorzella-Pezavento, Sofia Fernanda Gonçalves
Marques, Camila
França, Thais Graziela Donegá
Sartori, Alexandrina
Ikoma, Maura Rosane Valerio
da Rosa, Larissa Camargo

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-06-26

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Experimental autoimmune encephalomyelitis (EAE) is an artificially induced demyelination of the central nervous system (CNS) that resembles multiple sclerosis in its clinical, histopathological, and immunological features.

Activated Th1 and Th17 cells are thought to be the main immunological players during EAE development.

This study was designed to evaluate peripheral and local contribution of IL-17 to acute and chronic EAE stages.

C57BL/6 mice were immunized with MOG plus complete Freund’s adjuvant followed by pertussis toxin.

Mice presented an initial acute phase characterized by accentuated weight loss and high clinical score, followed by a partial recovery when the animals reached normal body weight and smaller clinical scores.

Spleen cells stimulated with MOG produced significantly higher levels of IFN-γ during the acute period whereas similar IL-17 levels were produced during both disease stages.

CNS-infiltrating cells stimulated with MOG produced similar amounts of IFN-γ but, IL-17 was produced only at the acute phase of EAE.

The percentage of Foxp3+ Treg cells, at the spleen and CNS, was elevated during both phases.

The degree of inflammation was similar at both disease stages.

Partial clinical recovery observed during chronic EAE was associated with no IL-17 production and presence of Foxp3+ Treg cells in the CNS.

American Psychological Association (APA)

Zorzella-Pezavento, Sofia Fernanda Gonçalves& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& da Rosa, Larissa Camargo& Marques, Camila…[et al.]. 2013. Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478187

Modern Language Association (MLA)

Zorzella-Pezavento, Sofia Fernanda Gonçalves…[et al.]. Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-478187

American Medical Association (AMA)

Zorzella-Pezavento, Sofia Fernanda Gonçalves& Chiuso-Minicucci, Fernanda& França, Thais Graziela Donegá& Ishikawa, Larissa Lumi Watanabe& da Rosa, Larissa Camargo& Marques, Camila…[et al.]. Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-478187

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-478187