The Characterization of Biological Rhythms in Mild Cognitive Impairment
Joint Authors
Martinez-Nicolas, Antonio
Rol, Maria Angeles
Pereda-Pérez, Inmaculada
Ortiz-Tudela, Elisabet
García-Herranz, Sara
Madrid, Juan Antonio
Venero, César
Peraita, Herminia
Valencia, Azucena
Díaz-Mardomingo, Carmen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Patients with dementia, especially Alzheimer’s disease, present several circadian impairments related to an accelerated perturbation of their biological clock that is caused by the illness itself and not merely age-related.
Thus, the objective of this work was to elucidate whether these circadian system alterations were already present in patients with mild cognitive impairment (MCI), as compared to healthy age-matched subjects.
Methods.
40 subjects (21 patients diagnosed with MCI, 74.1 ± 1.5 y.o., and 19 healthy subjects, 71.7 ± 1.4 y.o.) were subjected to ambulatory monitoring, recording wrist skin temperature, motor activity, body position, and the integrated variable TAP (including temperature, activity, and position) for one week.
Nonparametrical analyses were then applied.
Results.
MCI patients exhibited a significant phase advance with respect to the healthy group for the following phase markers: temperature M5 (mean ± SEM: 04:20 ± 00:21 versus 02:52 ± 00:21) and L10 (14:35 ± 00:27 versus 13:24 ± 00:16) and TAP L5 (04:18 ± 00:14 versus 02:55 ± 00:30) and M10 (14:30 ± 00:18 versus 13:28 ± 00:23).
Conclusions.
These results suggest that significant advances in the biological clock begin to occur in MCI patients, evidenced by an accelerated aging of the circadian clock, as compared to a healthy population of the same age.
American Psychological Association (APA)
Ortiz-Tudela, Elisabet& Martinez-Nicolas, Antonio& Díaz-Mardomingo, Carmen& García-Herranz, Sara& Pereda-Pérez, Inmaculada& Valencia, Azucena…[et al.]. 2014. The Characterization of Biological Rhythms in Mild Cognitive Impairment. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-478594
Modern Language Association (MLA)
Ortiz-Tudela, Elisabet…[et al.]. The Characterization of Biological Rhythms in Mild Cognitive Impairment. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-478594
American Medical Association (AMA)
Ortiz-Tudela, Elisabet& Martinez-Nicolas, Antonio& Díaz-Mardomingo, Carmen& García-Herranz, Sara& Pereda-Pérez, Inmaculada& Valencia, Azucena…[et al.]. The Characterization of Biological Rhythms in Mild Cognitive Impairment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-478594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478594