DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands
Joint Authors
Sourinejad, Noorkaram
Kashanian, Soheila
Shahabadi, Nahid
Mahdavi, Maryam
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A new Pt(II) complex, [Pt(DIP)(LL)](NO3)2 (in which DIP is 4,7-diphenyl-1,10-phenanthroline and LL is the aliphatic dinitrogen ligand, N,N-dimethyl-trimethylenediamine), was synthesized and characterized using different physico-chemical methods.
The interaction of this complex with calf thymus DNA (CT-DNA) was investigated by absorption, emission, circular dichroism (CD), and viscosity measurements.
The complex binds to CT-DNA in an intercalative mode.
The calculated binding constant, Kb, was 6.6×104 M−1.
The enthalpy and entropy changes of the reaction between the complex and CT-DNA showed that the van der Waals interactions and hydrogen bonds are the main forces in the interaction with CT-DNA.
In addition, CD study showed that phenanthroline ligand insert between the base pair stack of double helical structure of DNA.
It is remarkable that this complex has the ability to cleave the supercoiled plasmid.
American Psychological Association (APA)
Shahabadi, Nahid& Kashanian, Soheila& Mahdavi, Maryam& Sourinejad, Noorkaram. 2011. DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands. Bioinorganic Chemistry and Applications،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-478655
Modern Language Association (MLA)
Shahabadi, Nahid…[et al.]. DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands. Bioinorganic Chemistry and Applications No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-478655
American Medical Association (AMA)
Shahabadi, Nahid& Kashanian, Soheila& Mahdavi, Maryam& Sourinejad, Noorkaram. DNA Interaction and DNA Cleavage Studies of a New Platinum(II) Complex Containing Aliphatic and Aromatic Dinitrogen Ligands. Bioinorganic Chemistry and Applications. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-478655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478655