miRNAs and Melanoma : How Are They Connected?
Joint Authors
Cruz, Adriana Taveira da
Jasiulionis, Miriam Galvonas
Source
Dermatology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation.
It is predicted that over 30% of mRNAs are regulated by miRNAs.
Therefore these molecules are considered essential in the processing of many biological responses, such as cell proliferation, apoptosis, and stress responsiveness.
As miRNAs participate of virtually all cellular pathways, their deregulation is critical to cancer development.
Consequently, loss or gain of miRNAs function may contribute to tumor progression.
Little is known about the regulation of miRNAs and understanding the events that lead to changes in their expression may provide new perspectives for cancer treatment.
Among distinct types of cancer, melanoma has special implications.
It is characterized as a complex disease, originated from a malignant transformation of melanocytes.
Despite being rare, its metastatic form is usually incurable, which makes melanoma the major death cause of all skin cancers.
Some molecular pathways are frequently disrupted in melanoma, and miRNAs probably have a decisive role on these alterations.
Therefore, this review aims to discuss new findings about miRNAs in melanoma fields, underlying epigenetic processes, and also to argue possibilities of using miRNAs in melanoma diagnosis and therapy.
American Psychological Association (APA)
Cruz, Adriana Taveira da& Jasiulionis, Miriam Galvonas. 2011. miRNAs and Melanoma : How Are They Connected?. Dermatology Research and Practice،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-478880
Modern Language Association (MLA)
Cruz, Adriana Taveira da& Jasiulionis, Miriam Galvonas. miRNAs and Melanoma : How Are They Connected?. Dermatology Research and Practice No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-478880
American Medical Association (AMA)
Cruz, Adriana Taveira da& Jasiulionis, Miriam Galvonas. miRNAs and Melanoma : How Are They Connected?. Dermatology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-478880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478880