Interferonβ-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling
Joint Authors
Belur, Praveen
Mirshahpanah, Parham
Tran, Tiffany
Velichko, Sharlene
Croze, Ed
Yamaguchi, Ken D.
Reder, Anthony T.
Cifrese, Jill
Paz, Pedro
Ku, Karin
Source
International Journal of Cell Biology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We present evidence of a link between interferonβ-1b (IFN-β) and G-protein signaling by demonstrating that IFN-β can induce the expression of the negative regulator of G-protein signaling 1 (RGS1).
RGS1 reduces G-protein activation and immune cell migration by interacting with heterotrimeric G-proteins and enhancing their intrinsic GTPase activity.
In this study, IFN-β treatment resulted in the induction of RGS1 in peripheral blood mononuclear cells (PBMCs), monocytes, T cells, and B cells.
Induction of RGS1 by IFN-β was concentration dependent and observed at both the RNA and protein level.
Other members of the RGS family were not induced by IFN-β, and induction of RGS1 required the activation of the IFN receptor.
In addition, RGS1 induction was observed in PBMCs obtained from IFN-β-treated multiple sclerosis patients suggesting a possible, as yet unexplored, involvement of G-protein regulation in disease treatment.
The upregulation of RGS1 by IFN-β has not been previously reported.
American Psychological Association (APA)
Tran, Tiffany& Paz, Pedro& Velichko, Sharlene& Cifrese, Jill& Belur, Praveen& Yamaguchi, Ken D.…[et al.]. 2011. Interferonβ-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling. International Journal of Cell Biology،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-478997
Modern Language Association (MLA)
Tran, Tiffany…[et al.]. Interferonβ-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling. International Journal of Cell Biology No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-478997
American Medical Association (AMA)
Tran, Tiffany& Paz, Pedro& Velichko, Sharlene& Cifrese, Jill& Belur, Praveen& Yamaguchi, Ken D.…[et al.]. Interferonβ-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling. International Journal of Cell Biology. 2011. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-478997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-478997