The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases
Joint Authors
Godoy, Alejandro
Li, Yun
Mohler, James L.
Azzouni, Faris
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-25
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Despite the discovery of 5 alpha-reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha-reduced steroids in human diseases was not appreciated until the discovery of 5 alpha-reductase type 2 deficiency in 1974.
Affected males are born with ambiguous external genitalia, despite normal internal genitalia.
The prostate is hypoplastic, nonpalpable on rectal examination and approximately 1/10th the size of age-matched normal glands.
Benign prostate hyperplasia or prostate cancer does not develop in these patients.
At puberty, the external genitalia virilize partially, however, secondary sexual hair remains sparse and male pattern baldness and acne develop rarely.
Several compounds have been developed to inhibit the 5 alpha-reductase isozymes and they play an important role in the prevention and treatment of many common diseases.
This review describes the basic biochemical properties, functions, tissue distribution, chromosomal location, and clinical significance of the 5 alpha-reductase isozyme family.
American Psychological Association (APA)
Azzouni, Faris& Godoy, Alejandro& Li, Yun& Mohler, James L.. 2011. The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-479043
Modern Language Association (MLA)
Azzouni, Faris…[et al.]. The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-479043
American Medical Association (AMA)
Azzouni, Faris& Godoy, Alejandro& Li, Yun& Mohler, James L.. The 5 Alpha-Reductase Isozyme Family : A Review of Basic Biology and Their Role in Human Diseases. Advances in Urology. 2011. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-479043
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479043