Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5′-Substituted-2′-phenyl-1H-indol-3′-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives
Joint Authors
Katkar, Vijaykumar Tukaram
Saundane, Anand R.
Verma, Vaijinath A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The main aim of the present study was to synthesize new leads with potential antimicrobial and antioxidant activities.
As a part of systematic investigation of synthesis and biological activity, some new indole compounds 3a–c and 4a–c were prepared and screened for their antimicrobial and antioxidant activities.
The antimicrobial evaluation of newly synthesized compounds was carried out by cup-plate method.
Antimicrobial activity results revealed that compound 4a showed promising activity against bacteria Staphylococcus aureus, Klebsiella pneumonia, and Pseudomonas aeruginosa and exhibited maximum inhibition against Aspergillus niger, Aspergillus oryzae, Aspergillus terreus, and Aspergillus flavus.
The antioxidant activity was performed by three methods, namely, radical scavenging activity (RSA), ferric ions (Fe+3) reducing antioxidant power (FRAP), and metal chelating activity by using Hatano’s, Oyaizu’s, and Dinis' methods, respectively.
Compound 4a showed promising RSA, FRAP, and metal chelating activity.
American Psychological Association (APA)
Saundane, Anand R.& Katkar, Vijaykumar Tukaram& Verma, Vaijinath A.. 2013. Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5′-Substituted-2′-phenyl-1H-indol-3′-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479050
Modern Language Association (MLA)
Saundane, Anand R.…[et al.]. Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5′-Substituted-2′-phenyl-1H-indol-3′-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives. Journal of Chemistry No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-479050
American Medical Association (AMA)
Saundane, Anand R.& Katkar, Vijaykumar Tukaram& Verma, Vaijinath A.. Synthesis, Antimicrobial, and Antioxidant Activities of N-[(5′-Substituted-2′-phenyl-1H-indol-3′-yl)methylene]-5H-dibenzo[b,f]azepine-5-carbohydrazide Derivatives. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479050