Recipients with In Utero Induction of Tolerance Upregulated MHC Class I in the Engrafted Donor Skin
Joint Authors
Chang, Pei-Yeh
Yu, Hsiu-Yueh
Ou, Liang-Shiou
Chang, Hsueh-Ling
Chen, Jeng-Chang
Kuo, Ming-Ling
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The alterations in MHC class I expression play a crucial step in immune evasion of cancer or virus-infected cells.
This study aimed to examine whether tolerized grafts modified MHC class I expression.
FVB/N mice were rendered tolerant of C57BL/6 alloantigens by in utero transplantation of C57BL/6 marrows.
Postnatally, engrafted donor skins and leukocytes were examined for their MHC expression by quantitative real-time PCR and flow cytometry.
Engrafted donor skins upregulated their MHC class I related gene transcripts after short-term (1~2 weeks) or long-term (>1 month) engraftment.
This biological phenomenon was simultaneously associated with upregulation of TAP1 gene transcripts, suggesting an important role of TAP1 in the regulation of MHC class I pathway.
The surface MHC class I molecules of H-2Kb in engrafted donor leukocytes consistently showed overexpression.
Conclusively, the induction of allograft tolerance involved biological modifications of donor transplants.
The overexpression of MHC class I within engrafted transplants of tolerant mice might be used as the tolerance biomarkers for identifying a state of graft tolerance.
American Psychological Association (APA)
Chen, Jeng-Chang& Ou, Liang-Shiou& Yu, Hsiu-Yueh& Kuo, Ming-Ling& Chang, Pei-Yeh& Chang, Hsueh-Ling. 2014. Recipients with In Utero Induction of Tolerance Upregulated MHC Class I in the Engrafted Donor Skin. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479146
Modern Language Association (MLA)
Chen, Jeng-Chang…[et al.]. Recipients with In Utero Induction of Tolerance Upregulated MHC Class I in the Engrafted Donor Skin. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-479146
American Medical Association (AMA)
Chen, Jeng-Chang& Ou, Liang-Shiou& Yu, Hsiu-Yueh& Kuo, Ming-Ling& Chang, Pei-Yeh& Chang, Hsueh-Ling. Recipients with In Utero Induction of Tolerance Upregulated MHC Class I in the Engrafted Donor Skin. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-479146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479146