Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population
Joint Authors
Ishak, Ricardo
Rocha, Luciana L.
Almeida Lins, Pedro Alves de
Ferreira de Araújo, Marialva Tereza
Fonseca Filgueiras, Nathália Karla
Soares Monteiro, Julius Caesar Mendes
Bonfim Freitas, Felipe
Demachki, Sâmia
Silva dos Santos, Bruna Tereza
Ferreira, Vanessa M.
da Silva Conde, Simone Regina Souza
da Silva Graça, Ednelza
Rosário Vallinoto, Antonio Carlos
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia.
Methods.
In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were evaluated between May 2011 and December 2012.
The groups of patients were designated as inactive carriers, chronic hepatitis without cirrhosis, and chronic hepatitis with cirrhosis based on clinical, pathological, biochemical, hematological, and virological variables.
The patients were genotyped using quantitative real-time PCR.
Results.
The frequencies of the rs12979860 polymorphism were similar between the infected group (32.3% CC, 41.5% CT, and 26.2 TT) and the control population (35% CC, 47.4% CT, and 17.6% TT), and the frequencies of the rs8099917 polymorphism (7.7% GG, 35.4% GT, and 56.9% TT versus 7.2% GG, 35.1% GT, and 57.7% TT) were also similar in both groups.
The associations between the rs12979860 and rs8099917 polymorphisms and the clinical manifestations were not statistically significant.
Conclusion.
In conclusion, these polymorphisms had a similar distribution between infected and control groups, indicating that they were not associated with susceptibility and the clinical evolution of hepatitis B in the examined population.
American Psychological Association (APA)
da Silva Conde, Simone Regina Souza& Rocha, Luciana L.& Ferreira, Vanessa M.& Soares Monteiro, Julius Caesar Mendes& Fonseca Filgueiras, Nathália Karla& Almeida Lins, Pedro Alves de…[et al.]. 2014. Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-479369
Modern Language Association (MLA)
da Silva Conde, Simone Regina Souza…[et al.]. Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-479369
American Medical Association (AMA)
da Silva Conde, Simone Regina Souza& Rocha, Luciana L.& Ferreira, Vanessa M.& Soares Monteiro, Julius Caesar Mendes& Fonseca Filgueiras, Nathália Karla& Almeida Lins, Pedro Alves de…[et al.]. Absence of Correlation between IL-28B Gene Polymorphisms and the Clinical Presentation of Chronic Hepatitis B in an Amazon Brazilian Population. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-479369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479369