Amyotrophic Lateral Sclerosis and Metabolomics : Clinical Implication and Therapeutic Approach
Joint Authors
Ghosh, Devlina
Kumar, Alok
Singh, R. L.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is one of the most common motor neurodegenerative disorders, primarily affecting upper and lower motor neurons in the brain, brainstem, and spinal cord, resulting in paralysis due to muscle weakness and atrophy.
The majority of patients die within 3–5 years of symptom onset as a consequence of respiratory failure.
Due to relatively fast progression of the disease, early diagnosis is essential.
Metabolomics offer a unique opportunity to understand the spatiotemporal metabolic crosstalks through the assessment of body fluids and tissue.
So far, one of the most challenging issues related to ALS is to understand the variation of metabolites in body fluids and CNS with the progression of disease.
In this paper we will review the changes in metabolic profile in response to disease progression condition and also see the therapeutic implication of various drugs in ALS patients.
American Psychological Association (APA)
Kumar, Alok& Ghosh, Devlina& Singh, R. L.. 2013. Amyotrophic Lateral Sclerosis and Metabolomics : Clinical Implication and Therapeutic Approach. Journal of Biomarkers،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-479741
Modern Language Association (MLA)
Kumar, Alok…[et al.]. Amyotrophic Lateral Sclerosis and Metabolomics : Clinical Implication and Therapeutic Approach. Journal of Biomarkers No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-479741
American Medical Association (AMA)
Kumar, Alok& Ghosh, Devlina& Singh, R. L.. Amyotrophic Lateral Sclerosis and Metabolomics : Clinical Implication and Therapeutic Approach. Journal of Biomarkers. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-479741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479741