Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men

Joint Authors

Brixen, K.
Glintborg, Dorte
Christensen, L. L.
Andersen, M.
Richelsen, B.
Bruun, J. M.
Hougaard, D. M.
Kvorning, T.
Larsen, R.

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-08

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

Background.

The beneficial effects of testosterone treatment (TT) are debated.

Methods.

Double-blinded, placebo-controlled study of six months TT (gel) in 54 men aged 60–78 with bioavailable testosterone (BioT) <7.3 nmol/L and waist >94 cm randomized to TT (50–100 mg/day, n=20), placebo (n=18), or strength training (ST) (n=16) for 24 weeks.

Moreover, the ST group was randomized to TT (n=7) or placebo (n=9) after 12 weeks.

Outcomes.

Chemokines (MIF, MCP-1, and MIP-1α) and lean body mass (LBM), total, central, extremity, visceral, and subcutaneous (SAT) fat mass established by DXA and MRI.

Results.

From 0 to 24 weeks, MIF and SAT decreased during ST + placebo versus placebo, whereas BioT and LBM were unchanged.

TT decreased fat mass (total, central, extremity, and SAT) and increased BioT and LBM versus placebo.

MIF levels increased during TT versus ST + placebo.

ST + TT decreased fat mass (total, central, and extremity) and increased BioT and LBM versus placebo.

From 12 to 24 weeks, MCP-1 levels increased during TT versus placebo and MCP-1 levels decreased during ST + placebo versus placebo.

Conclusion.

ST + placebo was associated with decreased MIF levels suggesting decreased inflammatory activity.

TT may be associated with increased inflammatory activity.

This trial is registered with ClinicalTrials.gov NCT00700024.

American Psychological Association (APA)

Glintborg, Dorte& Christensen, L. L.& Kvorning, T.& Larsen, R.& Brixen, K.& Hougaard, D. M.…[et al.]. 2013. Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-479769

Modern Language Association (MLA)

Glintborg, Dorte…[et al.]. Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-479769

American Medical Association (AMA)

Glintborg, Dorte& Christensen, L. L.& Kvorning, T.& Larsen, R.& Brixen, K.& Hougaard, D. M.…[et al.]. Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-479769

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-479769