Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy
Joint Authors
Geboes, Karel
Abu El-Asrar, Ahmed M.
Nawaz, Mohd Imtiaz
Kangave, Dustan
Siddiquei, Mohammad Mairaj
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was conducted to determine levels of angiogenic and endothelial progenitor cell mobilizing (vasculogenic) factors in vitreous fluid from proliferative diabetic retinopathy (PDR) patients and correlate their levels with clinical disease activity.
Vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-2 (sVEGFR-2), stem cell factor (SCF), soluble c-kit (s-kit), endothelial nitric oxide synthase (eNOS), and prostaglandin E2 (PGE2) levels were measured by ELISA in vitreous samples from 34 PDR and 15 nondiabetic patients.
eNOS was not detected.
VEGF, sVEGFR-2, SCF, and s-kit levels were significantly higher in PDR with active neovascularization compared with quiescent PDR and nondiabetic patients (P<0.001; 0.007; 0.001; <0.001, resp.).
In contrast, PGE2 levels were significantly higher in nondiabetic patients compared with PDR patients (P<0.001).
There were significant correlations between levels of sVEGFR-2 versus SCF (r=0.950, P<0.001), sVEGFR-2 versus s-kit (r=0.941, P<0.001), and SCF versus s-kit (r=0.970, P<0.001).
Our findings suggest that upregulation of VEGF, sVEGFR-2, SCF, and s-kit supports the contributions of angiogenesis and vasculogenesis in pathogenesis of PDR.
American Psychological Association (APA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Siddiquei, Mohammad Mairaj& Geboes, Karel. 2013. Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479831
Modern Language Association (MLA)
Abu El-Asrar, Ahmed M.…[et al.]. Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Journal of Diabetes Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-479831
American Medical Association (AMA)
Abu El-Asrar, Ahmed M.& Nawaz, Mohd Imtiaz& Kangave, Dustan& Siddiquei, Mohammad Mairaj& Geboes, Karel. Angiogenic and Vasculogenic Factors in the Vitreous from Patients with Proliferative Diabetic Retinopathy. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-479831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-479831