Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis
Joint Authors
Kurtipek, Gulcan Saylam
Ataseven, Arzu
Ozturk, Perihan
Kesli, Recep
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Chronic inflammation may play a role in psoriasis pathogenesis.
Lipocalin 2, clusterin, soluble tumor necrosis factor receptor-1 (sTNFR-1), interleukin-6, homocysteine, and uric acid are inflammatory and/or biochemical markers.
However, both the roles of these markers and the pathogenesis of psoriasis are unknown.
Objective.
The aim of this study was to investigate serum levels of lipocalin 2, clusterin, sTNFR-1, interleukin-6, homocysteine, and uric acid in patients and controls groups.
Methods.
Fifty-six patients with psoriasis and 33 healthy controls were included in the study.
Serum concentrations of the markers were evaluated by ELISA.
The Psoriasis Area and Severity Index (PASI) was evaluated in all psoriasis patients.
Body mass index (BMI) was calculated by dividing weight (kg) by height (m) squared.
Results.
The serum value of lipocalin and sTNFR-1 were significantly higher in psoriasis patients than in controls (resp., P<0.001, P<0.05).
The others showed no significant differences between psoriasis and the control groups (all of them P>0.05).
The mean PASI score in the patient group was 8.3±6.5.
Conclusions.
These findings suggest that lipocalin 2 and sTNFR-1 might play a role in the pathogenesis of psoriasis and can be used as markers of the disease.
American Psychological Association (APA)
Ataseven, Arzu& Kesli, Recep& Kurtipek, Gulcan Saylam& Ozturk, Perihan. 2014. Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480025
Modern Language Association (MLA)
Ataseven, Arzu…[et al.]. Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-480025
American Medical Association (AMA)
Ataseven, Arzu& Kesli, Recep& Kurtipek, Gulcan Saylam& Ozturk, Perihan. Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480025