Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats
Joint Authors
Majzunova, Miroslava
Gajdosechová, Lucia
Dovinová, Ima
Chan, Julie Y. H.
Gresová, Linda
Cacanyiova, Sona
Kristek, Frantisek
Zorad, Stefan
Barancik, Miroslav
Balis, Peter
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
PPARγ receptor plays an important role in oxidative stress response.
Its agonists can influence vascular contractility in experimental hypertension.
Our study was focused on the effects of a PPARγ agonist pioglitazone (PIO) on blood pressure regulation, vasoactivity of vessels, and redox-sensitive signaling at the central (brainstem, BS) and peripheral (left ventricle, LV) levels in young prehypertensive rats.
5-week-old SHR were treated either with PIO (10 mg/kg/day, 2 weeks) or with saline using gastric gavage.
Administration of PIO significantly slowed down blood pressure increase and improved lipid profile and aortic relaxation after insulin stimulation.
A significant increase in PPARγ expression was found only in BS, not in LV.
PIO treatment did not influence NOS changes, but had tissue-dependent effect on SOD regulation and increased SOD activity, observed in LV.
The treatment with PIO differentially affected also the levels of other intracellular signaling components: Akt kinase increased in the the BS, while β-catenin level was down-regulated in the BS and up-regulated in the LV.
We found that the lowering of blood pressure in young SHR can be connected with insulin sensitivity of vessels and that β-catenin and SOD levels are important agents mediating PIO effects in the BS and LV.
American Psychological Association (APA)
Dovinová, Ima& Barancik, Miroslav& Majzunova, Miroslava& Zorad, Stefan& Gajdosechová, Lucia& Gresová, Linda…[et al.]. 2013. Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats. PPAR Research،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-480048
Modern Language Association (MLA)
Dovinová, Ima…[et al.]. Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats. PPAR Research No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-480048
American Medical Association (AMA)
Dovinová, Ima& Barancik, Miroslav& Majzunova, Miroslava& Zorad, Stefan& Gajdosechová, Lucia& Gresová, Linda…[et al.]. Effects of PPARγ Agonist Pioglitazone on Redox-Sensitive Cellular Signaling in Young Spontaneously Hypertensive Rats. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-480048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480048