Diagnostic Features and Subtyping of Thymoma Lymph Node Metastases
Joint Authors
Gallo, Enzo
Marino, Mirella
Melis, Enrico
Rinaldi, Massimo
Evoli, Amelia
Lalle, Maurizio
Pescarmona, Edoardo
Palmieri, Giovannella
Pizzi, Giuseppe
Martucci, Robert
Facciolo, Francesco
Lauriola, Libero
Sioletic, Stefano
Granone, Pierluigi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
The purpose of the present study was to characterize the morphological features of thymoma metastases in lymph nodes and to evaluate the possibility of their subtyping according to the 2004 WHO classification of thymus tumors.
Materials and Methods.
We reviewed 210 thymoma cases in our series of thymic epithelial tumors (TET), including their recurrences and lymphogenous metastases.
Three cases of lymph node metastases, one case occurring synchronously with the primary tumor and one synchronously with the first relapse (both in intrathoracic location) and one case of metastasis observed in a laterocervical lymph node subsequently to two thymoma relapses were found.
Results.
The metastatic nodes were variably but extensively involved in all cases.
The histological features were similar in both primary tumors and metastases.
Thymoma metastases were subtyped according to the WHO classification as B3 (one case) and B2 (two cases), and distinctive features in comparison to metastatic epithelial neoplasias from other sites were observed.
Conclusion.
Thymoma lymph node metastases, although rare, can be subtyped according to the WHO classification on the basis of their morphological and immunohistochemical features.
Clinically, the presence of nodal metastases may herald subsequent relapses and further metastases even in extrathoracic sites.
American Psychological Association (APA)
Sioletic, Stefano& Lauriola, Libero& Gallo, Enzo& Martucci, Robert& Evoli, Amelia& Palmieri, Giovannella…[et al.]. 2014. Diagnostic Features and Subtyping of Thymoma Lymph Node Metastases. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-480343
Modern Language Association (MLA)
Sioletic, Stefano…[et al.]. Diagnostic Features and Subtyping of Thymoma Lymph Node Metastases. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-480343
American Medical Association (AMA)
Sioletic, Stefano& Lauriola, Libero& Gallo, Enzo& Martucci, Robert& Evoli, Amelia& Palmieri, Giovannella…[et al.]. Diagnostic Features and Subtyping of Thymoma Lymph Node Metastases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-480343
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480343