Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−− Mice
Joint Authors
Bernberg, Evelina
Bergström, Göran M. L.
Johansson, Maria E.
Ulleryd, Marcus A.
Yang, Li Jin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A few studies in animals and humans suggest that metoprolol (β1-selective adrenoceptor antagonist) may have a direct antiatherosclerotic effect.
However, the mechanism behind this protective effect has not been established.
The aim of the present study was to evaluate the effect of metoprolol on development of atherosclerosis in ApoE−/− mice and investigate its effect on the release of proinflammatory cytokines.
Male ApoE−/− mice were treated with metoprolol (2.5 mg/kg/h) or saline for 11 weeks via osmotic minipumps.
Atherosclerosis was assessed in thoracic aorta and aortic root.
Total cholesterol levels and Th1/Th2 cytokines were analyzed in serum and macrophage content in lesions by immunohistochemistry.
Metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta (P<0.05 versus Control).
Further, metoprolol reduced serum TNFα and the chemokine CXCL1 (P<0.01 versus Control for both) as well as decreasing the macrophage content in the plaques (P<0.01 versus Control).
Total cholesterol levels were not affected.
In this study we found that a moderate dose of metoprolol significantly reduced atherosclerotic plaque area in thoracic aorta of ApoE−/− mice.
Metoprolol also decreased serum levels of proinflammatory cytokines TNFα and CXCL1 and macrophage content in the plaques, showing that metoprolol has an anti-inflammatory effect.
American Psychological Association (APA)
Ulleryd, Marcus A.& Bernberg, Evelina& Yang, Li Jin& Bergström, Göran M. L.& Johansson, Maria E.. 2014. Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−− Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480597
Modern Language Association (MLA)
Ulleryd, Marcus A.…[et al.]. Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−− Mice. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-480597
American Medical Association (AMA)
Ulleryd, Marcus A.& Bernberg, Evelina& Yang, Li Jin& Bergström, Göran M. L.& Johansson, Maria E.. Metoprolol Reduces Proinflammatory Cytokines and Atherosclerosis in ApoE−− Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-480597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-480597