Norfloxacin—Toxicity for Zebrafish (Danio rerio)‎ Focused on Oxidative Stress Parameters

Abstract EN

The aim of the study was to investigate the effects of subchronic exposure of zebrafish (Danio rerio) to a fluoroquinolone norfloxacin, using selected oxidative stress parameters as a target.

Toxicity tests were performed on zebrafish according to the OECD Guidelines number 203 and number 215.

In the Subchronic Toxicity Test, a significant (P<0.01) increase in the activity of glutathione peroxidase, glutathione S-transferase, and catalase was found.

In the test, norfloxacin did not affect lipid peroxidation and catalytic activity of glutathione reductase.

From the results, we can conclude that norfloxacin has a negative impact on specific biochemical processes connected with the production of reactive oxygen species in fish tested.