Effect of Tumor Necrosis Factor-α on Neutralization of Ventricular Fibrillation in Rats with Acute Myocardial Infarction
Joint Authors
Cao, Zhe
Zhang, Qing
Chen, Yu
Chen, Zhi-Jian
Liao, Yu-Hua
Yang, Hua
Du, Yi-Mei
Xia, Jia-Ding
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to explore the effects of tumor necrosis factor-α (TNF-α) on ventricular fibrillation (VF) in rats with acute myocardial infarction (AMI).
Rats were randomly classified into AMI group, sham operation group and recombinant human tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) group.
Spontaneous and induced VFs were recorded.
Monophasic action potentials (MAPs) among different zones of myocardium were recorded at eight time points before and after ligation and MAP duration dispersions (MAPDds) were calculated.
Then expression of TNF-α among different myocardial zones was detected.
After ligation of the left anterior descending coronary artery, total TNF-α expression in AMI group began to markedly increase at 10 min, reached a climax at 20–30min, and then gradually decreased.
The time-windows of VFs and MAPDds in the border zone performed in a similar way.
At the same time-point, the expression of TNF-α in the ischemia zone was greater than that in the border zone, and little in the non-ischemia zone.
Although the time windows of TNF-α expression, the MAPDds in the border zone and the occurrence of VFs in the rhTNFR:Fc group were similar to those in the AMI group, they all decreased in the rhTNFR:Fc group.
Our findings demonstrate that TNF-α could enlarge the MAPDds in the border zone, and promote the onset of VFs.
American Psychological Association (APA)
Chen, Yu& Zhang, Qing& Liao, Yu-Hua& Cao, Zhe& Du, Yi-Mei& Xia, Jia-Ding…[et al.]. 2011. Effect of Tumor Necrosis Factor-α on Neutralization of Ventricular Fibrillation in Rats with Acute Myocardial Infarction. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-481217
Modern Language Association (MLA)
Chen, Yu…[et al.]. Effect of Tumor Necrosis Factor-α on Neutralization of Ventricular Fibrillation in Rats with Acute Myocardial Infarction. Mediators of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-481217
American Medical Association (AMA)
Chen, Yu& Zhang, Qing& Liao, Yu-Hua& Cao, Zhe& Du, Yi-Mei& Xia, Jia-Ding…[et al.]. Effect of Tumor Necrosis Factor-α on Neutralization of Ventricular Fibrillation in Rats with Acute Myocardial Infarction. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-481217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481217