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Co-localization of the PDGF β-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts
Joint Authors
Boonstra, Johannes
Zhou, Yeping
Moes, Maarten J. A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-19
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The subcellular localization of the PDGF β-receptor was investigated in relation with PDGF-induced actin and membrane dynamics in mouse C3H10T1/2 fibroblasts.
Serum-starved cells exhibit a nonhomogenous distribution of PDGF β-receptors.
However, the observed pattern does not resemble the localization of PDGF-induced actin structures.
Interestingly, the PDGF β-receptor showed a changed subcellular distribution in relation to the formation of PDGF-BB-induced actin structures.
Upon PDGF exposure, PDGF β-receptors were found to accumulate in dorsal circular ruffles.
The presence of both macropinosomes and clathrin in the induced circular ruffles suggests that the accumulation of PDGF β-receptors in circular ruffles results in the efficient internalization of PDGF β-receptors.
American Psychological Association (APA)
Moes, Maarten J. A.& Zhou, Yeping& Boonstra, Johannes. 2012. Co-localization of the PDGF β-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts. ISRN Cell Biology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-481367
Modern Language Association (MLA)
Moes, Maarten J. A.…[et al.]. Co-localization of the PDGF β-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts. ISRN Cell Biology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-481367
American Medical Association (AMA)
Moes, Maarten J. A.& Zhou, Yeping& Boonstra, Johannes. Co-localization of the PDGF β-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts. ISRN Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-481367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481367