Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer
Joint Authors
Bonomi, Serena
Karni, Rotem
Ghigna, Claudia
Siegfried, Zahava
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alternative splicing is a fundamental step in regulation of gene expression of many tumor suppressors and oncogenes in cancer.
Signalling through the Ras-MAPK and PI3K-mTOR pathways is misregulated and hyperactivated in most types of cancer.
However, the regulation of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing is less well established.
Recent studies have shown the contribution of alternative splicing regulation of these signalling pathways which can lead to cellular transformation, cancer development, and tumor maintenance.
This review will discuss findings in the literature which describe new modes of regulation of components of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing.
We will also describe the mechanisms by which signals from extracellular stimuli can be communicated to the splicing machinery and to specific RNA-binding proteins that ultimately control exon definition events.
American Psychological Association (APA)
Siegfried, Zahava& Bonomi, Serena& Ghigna, Claudia& Karni, Rotem. 2013. Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481439
Modern Language Association (MLA)
Siegfried, Zahava…[et al.]. Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-481439
American Medical Association (AMA)
Siegfried, Zahava& Bonomi, Serena& Ghigna, Claudia& Karni, Rotem. Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481439