Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer

Joint Authors

Bonomi, Serena
Karni, Rotem
Ghigna, Claudia
Siegfried, Zahava

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-03

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Alternative splicing is a fundamental step in regulation of gene expression of many tumor suppressors and oncogenes in cancer.

Signalling through the Ras-MAPK and PI3K-mTOR pathways is misregulated and hyperactivated in most types of cancer.

However, the regulation of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing is less well established.

Recent studies have shown the contribution of alternative splicing regulation of these signalling pathways which can lead to cellular transformation, cancer development, and tumor maintenance.

This review will discuss findings in the literature which describe new modes of regulation of components of the Ras-MAPK and PI3K-mTOR signalling pathways by alternative splicing.

We will also describe the mechanisms by which signals from extracellular stimuli can be communicated to the splicing machinery and to specific RNA-binding proteins that ultimately control exon definition events.

American Psychological Association (APA)

Siegfried, Zahava& Bonomi, Serena& Ghigna, Claudia& Karni, Rotem. 2013. Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481439

Modern Language Association (MLA)

Siegfried, Zahava…[et al.]. Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-481439

American Medical Association (AMA)

Siegfried, Zahava& Bonomi, Serena& Ghigna, Claudia& Karni, Rotem. Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-481439

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-481439