Rodent Preclinical Models for Developing Novel Antiarthritic Molecules : Comparative Biology and Preferred Methods for Evaluating Efficacy
Joint Authors
King, Caroline
Feige, Ulrich
Stolina, Marina
Middleton, Scot
Bolon, Brad
Zack, Debra
Gasser, Jill
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Rodent models of immune-mediated arthritis (RMIA) are the conventional approach to evaluating mechanisms of inflammatory joint disease and the comparative efficacy of antiarthritic agents.
Rat adjuvant-induced (AIA), collagen-induced (CIA), and streptococcal cell wall-induced (SCW) arthritides are preferred models of the joint pathology that occurs in human rheumatoid arthritis (RA).
Lesions of AIA are most severe and consistent; structural and immunological changes of CIA best resemble RA.
Lesion extent and severity in RMIA depends on experimental methodology (inciting agent, adjuvant, etc.) and individual physiologic parameters (age, genetics, hormonal status, etc.).
The effectiveness of antiarthritic molecules varies with the agent, therapeutic regimen, and choice of RMIA.
All RMIA are driven by overactivity of proinflammatory pathways, but the dominant molecules differ among the models.
Hence, as with the human clinical experience, the efficacy of various antiarthritic molecules differs among RMIA, especially when the agent is a specific cytokine inhibitor.
American Psychological Association (APA)
Bolon, Brad& Stolina, Marina& King, Caroline& Middleton, Scot& Gasser, Jill& Zack, Debra…[et al.]. 2010. Rodent Preclinical Models for Developing Novel Antiarthritic Molecules : Comparative Biology and Preferred Methods for Evaluating Efficacy. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-481454
Modern Language Association (MLA)
Bolon, Brad…[et al.]. Rodent Preclinical Models for Developing Novel Antiarthritic Molecules : Comparative Biology and Preferred Methods for Evaluating Efficacy. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-21.
https://search.emarefa.net/detail/BIM-481454
American Medical Association (AMA)
Bolon, Brad& Stolina, Marina& King, Caroline& Middleton, Scot& Gasser, Jill& Zack, Debra…[et al.]. Rodent Preclinical Models for Developing Novel Antiarthritic Molecules : Comparative Biology and Preferred Methods for Evaluating Efficacy. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-21.
https://search.emarefa.net/detail/BIM-481454
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481454