Role of PPARα in Hepatic Carbohydrate Metabolism

Abstract EN

Tight control of storage and synthesis of glucose during nutritional transitions is essential to maintain blood glucose levels, a process in which the liver has a central role.

PPARα is the master regulator of lipid metabolism during fasting, but evidence is emerging for a role of PPARα in balancing glucose homeostasis as well.

By using PPARα ligands and PPARα−/− mice, several crucial genes were shown to be regulated by PPARα in a direct or indirect way.

We here review recent evidence that PPARα contributes to the adaptation of hepatic carbohydrate metabolism during the fed-to-fasted or fasted-to-fed transition in rodents.