Use of Poly (ε-Lysine) Dendrons : A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation
Joint Authors
James, Stuart L.
Issa, Rahaf
Cooper, Ian R.
Meikle, Steve T.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Pseudomonas aeruginosa is recognised as a major aetiological agent of nosocomial infections, which are associated with multiple-antibiotic resistance.
Among many of its important virulence factors is its ability to form biofilms on the surfaces of implantable medical devices and to produce toxic metabolites, pyocyanin, via an intercellular cell density-dependent signalling system of communication.
In this study, poly (ε-lysine) dendrons composed of increasingly branching generations were synthesised, characterised, and examined for their effects on virulence factor production in P.
aeruginosa.
The results show that these hyperbranched poly (ε-lysine) dendrons, in particular the 3rd generation, can increase the efficacy of a conventional antibiotic, ciprofloxacin, and reduce pyocyanin production, with marginal effects on the rate of bacterial replication, suggesting that the observed effects are not due to dendron toxicity.
Furthermore, dendron and ciprofloxacin coadministration was identified as the most effective strategy which highlights the potential of peptide-based dendrons as quorum sensing inhibitors.
American Psychological Association (APA)
Issa, Rahaf& Meikle, Steve T.& James, Stuart L.& Cooper, Ian R.. 2014. Use of Poly (ε-Lysine) Dendrons : A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481803
Modern Language Association (MLA)
Issa, Rahaf…[et al.]. Use of Poly (ε-Lysine) Dendrons : A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation. Conference Papers in Science No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-481803
American Medical Association (AMA)
Issa, Rahaf& Meikle, Steve T.& James, Stuart L.& Cooper, Ian R.. Use of Poly (ε-Lysine) Dendrons : A Strategy Targeting Bacterial Quorum Sensing and Biofilm Formation. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-481803
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-481803