Scientific Rationale for the Use of Alpha-Adrenergic Agonists and Glucocorticoids in the Therapy of Pediatric Stridor
Joint Authors
Nino, Gustavo
Gutierrez, Maria J.
Baloglu, Orkun
Schwartz, Michael
Source
International Journal of Otolaryngology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Purpose.
The most common pharmacological therapies used in the treatment of stridor in children are glucocorticosteroids (GC) and alpha-adrenergic (αAR) agonists.
Despite the long-standing reported efficacy of these medications, there is a paucity of data relating to their actual mechanisms of action in the upper airway.
Summary.
There is compelling scientific evidence supporting the use of αAR-agonists and GCs in pediatric stridor.
αAR signaling and GCs regulate the vasomotor tone in the upper airway mucosa.
The latter translates into better airflow dynamics, as delineated by human and nonhuman upper airway physiological models.
In turn, clinical trials have demonstrated that GCs and the nonselective αAR agonist, epinephrine, improve respiratory distress scores and reduce the need for further medical care in children with stridor.
Future research is needed to investigate the role of selective αAR agonists and the potential synergism of GCs and αAR-signaling in the treatment of upper airway obstruction and stridor.
American Psychological Association (APA)
Nino, Gustavo& Baloglu, Orkun& Gutierrez, Maria J.& Schwartz, Michael. 2011. Scientific Rationale for the Use of Alpha-Adrenergic Agonists and Glucocorticoids in the Therapy of Pediatric Stridor. International Journal of Otolaryngology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-482003
Modern Language Association (MLA)
Nino, Gustavo…[et al.]. Scientific Rationale for the Use of Alpha-Adrenergic Agonists and Glucocorticoids in the Therapy of Pediatric Stridor. International Journal of Otolaryngology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-482003
American Medical Association (AMA)
Nino, Gustavo& Baloglu, Orkun& Gutierrez, Maria J.& Schwartz, Michael. Scientific Rationale for the Use of Alpha-Adrenergic Agonists and Glucocorticoids in the Therapy of Pediatric Stridor. International Journal of Otolaryngology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-482003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482003