Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine
Joint Authors
Lin, Chunmei
Lee, Jong Geol
Nam, Sang-Yoon
Jung, Ki Youn
Jung, A Young
Yon, Jung-Min
Lee, Beom Jun
Yun, Young Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
After maternal intake, nicotine crosses the placental barrier and causes severe embryonic disorders and fetal death.
In this study, we investigated whether β-carotene has a beneficial effect against nicotine-induced teratogenesis in mouse embryos (embryonic day 8.5) cultured for 48 h in a whole embryo culture system.
Embryos exposed to nicotine (1 mM) exhibited severe morphological anomalies and apoptotic cell death, as well as increased levels of TNF-α, IL-1β, and caspase 3 mRNAs, and lipid peroxidation.
The levels of cytoplasmic superoxide dismutase (SOD), mitochondrial manganese-dependent SOD, cytosolic glutathione peroxidase (GPx), phospholipid hydroperoxide GPx, hypoxia inducible factor 1α, and Bcl-xL mRNAs decreased, and SOD activity was reduced compared to the control group.
However, when β-carotene (1×10−7 or 5×10−7μM) was present in cultures of embryos exposed to nicotine, these parameters improved significantly.
These findings indicate that β-carotene effectively protects against nicotine-induced teratogenesis in mouse embryos through its antioxidative, antiapoptotic, and anti-inflammatory activities.
American Psychological Association (APA)
Lin, Chunmei& Yon, Jung-Min& Jung, A Young& Lee, Jong Geol& Jung, Ki Youn& Lee, Beom Jun…[et al.]. 2013. Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-482025
Modern Language Association (MLA)
Lin, Chunmei…[et al.]. Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-482025
American Medical Association (AMA)
Lin, Chunmei& Yon, Jung-Min& Jung, A Young& Lee, Jong Geol& Jung, Ki Youn& Lee, Beom Jun…[et al.]. Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-482025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482025