Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor deficits accompanying degeneration of substantia nigra pars compactor (SNc) neurons.
Although familial forms of the disease exist, the cause of sporadic PD is unknown.
Symptomatic treatments are available for PD, but there are no disease modifying therapies.
While the neurodegenerative processes in PD may be multifactorial, this paper will review the evidence that prooxidant iron elevation in the SNc is an invariable feature of sporadic and familial PD forms, participates in the disease mechanism, and presents as a tractable target for a disease modifying therapy.
American Psychological Association (APA)
Ayton, Scott& Lei, Peng. 2014. Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-482480
Modern Language Association (MLA)
Ayton, Scott& Lei, Peng. Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-482480
American Medical Association (AMA)
Ayton, Scott& Lei, Peng. Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-482480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482480