Inhibition of LXRαSREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule
Joint Authors
Wang, Miao
Xing, Lian-Jun
Sun, Shanshan
Hao, Weiwei
Zhang, Li
Zheng, Pei-Yong
Wu, Tao
Ji, Guang
Song, Hai-Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nonalcoholic fatty liver (NAFL) is increasingly recognized as one of the most common causes of chronic liver disease worldwide.
Traditional Chinese medicine (TCM), as the alternative and complementary medicine, may provide some profound health benefit.
“Jiang-Zhi” Granule (JZG) was composed based on TCM pathogenesis of NAFL: the retention of inner dampness, heat and blood stasis.
This study investigated effects of JZG on liver X receptor-α (LXRα)/sterol regulatory element binding protein-1c (SREBP-1c) pathway in high-fat-diet-(HFD-)induced hepatic steatosis, as well as in free-fatty-acid-(FFA-)and T0901317-treated HepG2 cells.
The results showed that JZG had an antisteatotic effect on HFD-fed rats.
JZG decreased the activation of SREBP-1c through inhibiting LXRα-mediated SREBP-1c transcription, as well as through inhibiting the maturation of SREBP-1c independent of LXRα.
These findings may provide molecular evidence for the use of JZG as a promising therapeutic option for NAFL and support us to continue JZG treatment in NAFL.
For JZG treatment to be widely accepted, a randomized, double-blind, multicenter, placebo-controlled, phase III trial is ongoing.
American Psychological Association (APA)
Wang, Miao& Sun, Shanshan& Wu, Tao& Zhang, Li& Song, Hai-Yan& Hao, Weiwei…[et al.]. 2013. Inhibition of LXRαSREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-482779
Modern Language Association (MLA)
Wang, Miao…[et al.]. Inhibition of LXRαSREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-482779
American Medical Association (AMA)
Wang, Miao& Sun, Shanshan& Wu, Tao& Zhang, Li& Song, Hai-Yan& Hao, Weiwei…[et al.]. Inhibition of LXRαSREBP-1c-Mediated Hepatic Steatosis by Jiang-Zhi Granule. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-482779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482779