Decrease of Obesity by Allantoin via Imidazoline I1-Receptor Activation in High Fat Diet-Fed Mice
Joint Authors
Chung, Hsien-Hui
Cheng, Juei-Tang
Lee, Kung Shing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The activation of the imidazoline I1-receptor (I1R) is known to regulate appetite.
Allantoin, an active ingredient in the yam, has been reported to improve lipid metabolism in high fat diet- (HFD-)fed mice.
However, the effect of allantoin on obesity remains unclear.
In the present study, we investigated the effects of allantoin on HFD-induced obesity.
The chronic administration of allantoin to HFD-fed mice for 8 weeks significantly decreased their body weight, and this effect was reversed by efaroxan at a dose sufficient to block I1R.
The epididymal white adipose tissue (eWAT) cell size and weight in HFD-fed mice were also decreased by allantoin via the activation of I1R.
In addition, allantoin significantly decreased the energy intake of HFD-fed mice, and this reduction was associated with a decrease in the NPY levels in the brain.
However, no inhibitory effect of allantoin on energy intake was observed in db/db mice.
Moreover, allantoin lowered HFD-induced hyperleptinemia, and this activity was abolished by I1R blockade with efaroxan.
Taken together, these data suggest that allantoin can ameliorate energy intake and eWAT accumulation by activating I1R to improve HFD-induced obesity.
American Psychological Association (APA)
Chung, Hsien-Hui& Lee, Kung Shing& Cheng, Juei-Tang. 2013. Decrease of Obesity by Allantoin via Imidazoline I1-Receptor Activation in High Fat Diet-Fed Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-483128
Modern Language Association (MLA)
Chung, Hsien-Hui…[et al.]. Decrease of Obesity by Allantoin via Imidazoline I1-Receptor Activation in High Fat Diet-Fed Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-483128
American Medical Association (AMA)
Chung, Hsien-Hui& Lee, Kung Shing& Cheng, Juei-Tang. Decrease of Obesity by Allantoin via Imidazoline I1-Receptor Activation in High Fat Diet-Fed Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-483128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483128