Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation
Joint Authors
Lin, Chien-Hung
Wei, Yau-Huei
Shen, Yao-An
Wang, Chia-Yu
Hsieh, Yi-Tao
Chi, Wei-Hsin
Chen, Yann-Jang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cancer stem cells (CSCs) are able to self-renew and are refractory to cancer treatment.
To investigate the effects of resveratrol on CSCs of nasopharyngeal carcinoma (NPC), we employed a behavior selection strategy to isolate CSCs based on radioresistance, chemoresistance, and tumor sphere formation ability.
These NPC CSCs displayed stem cell properties and underwent metabolic shift to predominately rely on glycolysis for energy supply.
Intriguingly, we found that resveratrol turned off the metabolic switch, increased the reactive oxygen species (ROS) level, and depolarized mitochondrial membranes.
These alterations in metabolism occurred concomitantly with the suppression of CSC properties including resistance to therapy, self-renewal capacity, tumor initiation capacity, and metastatic potential in NPC CSCs.
We found that resveratrol impeded CSC properties through the activation of p53 and this effect could be reversed by knockdown of p53.
Furthermore, resveratrol suppressed the stemness and EMT through reactivating p53 and inducing miR-145 and miR-200c, which were downregulated in NPC CSCs.
In conclusion, we demonstrated that resveratrol employed the p53 pathway in regulating stemness, EMT, and metabolic reprogramming.
Further investigation of the molecular mechanism of p53 activation by resveratrol may provide useful information for the development of novel therapies for cancer treatment through targeting to CSCs.
American Psychological Association (APA)
Shen, Yao-An& Lin, Chien-Hung& Chi, Wei-Hsin& Wang, Chia-Yu& Hsieh, Yi-Tao& Wei, Yau-Huei…[et al.]. 2013. Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-483228
Modern Language Association (MLA)
Shen, Yao-An…[et al.]. Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-483228
American Medical Association (AMA)
Shen, Yao-An& Lin, Chien-Hung& Chi, Wei-Hsin& Wang, Chia-Yu& Hsieh, Yi-Tao& Wei, Yau-Huei…[et al.]. Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-483228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483228