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Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells
Joint Authors
Tone, Luiz Gonzaga
de Oliveira, H. F.
Roberto, G. M.
Morales, A. G.
Valera, E. T.
Umezawa, K.
Pezuk, J. A.
Brassesco, María Sol
Scrideli, Carlos Alberto
Delsin, L. E. A.
Rego, E. M.
Carlotti Jr., C. G.
Oliveira, J. C.
Source
Chemotherapy Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Despite advances in neurosurgery and aggressive treatment with temozolomide (TMZ) and radiation, the overall survival of patients with glioblastoma (GBM) remains poor.
Vast evidence has indicated that the nuclear factor NF-κB is constitutively activated in cancer cells, playing key roles in growth and survival.
Recently, Dehydroxymethylepoxyquinomicin (DHMEQ) has shown to be a selective NF-κB inhibitor with antiproliferative properties in GBM.
In the present study, the ability of DHMEQ to surmount tumor's invasive nature and therapy resistance were further explored.
Corroborating results showed that DHMEQ impaired cell growth in dose- and time-dependent manners with G2/M arrest when compared with control.
Clonogenicity was also significantly diminished with increased apoptosis, though necrotic cell death was also observed at comparable levels.
Notably, migration and invasion were inhibited accordingly with lowered expression of invasion-related genes.
Moreover, concurrent combination with TMZ synergistically inhibited cell growth in all cell lines, as determined by proliferation and caspase-3 activation assays, though in those that express O6-methylguanine-DNA methyltransferase, the synergistic effects were schedule dependent.
Pretreatment with DHMEQ equally sensitized cells to ionizing radiation.
Taken together, our results strengthen the potential usefulness of DHMEQ in future therapeutic strategies for tumors that do not respond to conventional approaches.
American Psychological Association (APA)
Brassesco, María Sol& Roberto, G. M.& Morales, A. G.& Oliveira, J. C.& Delsin, L. E. A.& Pezuk, J. A.…[et al.]. 2013. Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells. Chemotherapy Research and Practice،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-483493
Modern Language Association (MLA)
Brassesco, María Sol…[et al.]. Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells. Chemotherapy Research and Practice No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-483493
American Medical Association (AMA)
Brassesco, María Sol& Roberto, G. M.& Morales, A. G.& Oliveira, J. C.& Delsin, L. E. A.& Pezuk, J. A.…[et al.]. Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells. Chemotherapy Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-483493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483493