Boldine Prevents Renal Alterations in Diabetic Rats
Joint Authors
Velarde, Victoria
Boric, Mauricio P.
Hernández-Salinas, Romina
Arismendi, Marlene N.
Vielma, Alejandra Z.
Sáez, Juan C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic nephropathy alters both structure and function of the kidney.
These alterations are associated with increased levels of reactive oxygen species, matrix proteins, and proinflammatory molecules.
Inflammation decreases gap junctional communication and increases hemichannel activity leading to increased membrane permeability and altering tissue homeostasis.
Since current treatments for diabetic nephropathy do not prevent renal damage, we postulated an alternative treatment with boldine, an alkaloid obtained from boldo with antioxidant, anti-inflammatory, and hypoglycemic effects.
Streptozotocin-induced diabetic and control rats were treated or not treated with boldine (50 mg/Kg/day) for ten weeks.
In addition, mesangial cells were cultured under control conditions or in high glucose concentration plus proinflammatory cytokines, with or without boldine (100 µmol/L).
Boldine treatment in diabetic animals prevented the increase in glycemia, blood pressure, renal thiobarbituric acid reactive substances and the urinary protein/creatinine ratio.
Boldine also reduced alterations in matrix proteins and markers of renal damage.
In mesangial cells, boldine prevented the increase in oxidative stress, the decrease in gap junctional communication, and the increase in cell permeability due to connexin hemichannel activity induced by high glucose and proinflammatory cytokines but did not block gap junction channels.
Thus boldine prevented both renal and cellular alterations and could be useful for preventing tissue damage in diabetic subjects.
American Psychological Association (APA)
Hernández-Salinas, Romina& Vielma, Alejandra Z.& Arismendi, Marlene N.& Boric, Mauricio P.& Sáez, Juan C.& Velarde, Victoria. 2013. Boldine Prevents Renal Alterations in Diabetic Rats. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-483559
Modern Language Association (MLA)
Hernández-Salinas, Romina…[et al.]. Boldine Prevents Renal Alterations in Diabetic Rats. Journal of Diabetes Research No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-483559
American Medical Association (AMA)
Hernández-Salinas, Romina& Vielma, Alejandra Z.& Arismendi, Marlene N.& Boric, Mauricio P.& Sáez, Juan C.& Velarde, Victoria. Boldine Prevents Renal Alterations in Diabetic Rats. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-483559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483559