Strategies for Cancer Vaccine Development
Joint Authors
Tsang, Kwong Y.
Intrivici, Chiara
Schlom, Jeffrey
Huen, Ngar-Yee
Vergati, Matteo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Treating cancer with vaccines has been a challenging field of investigation since the 1950s.
Over the years, the lack of effective active immunotherapies has led to the development of numerous novel strategies.
However, the use of therapeutic cancer vaccines may be on the verge of becoming an effective modality.
Recent phase II/III clinical trials have achieved hopeful results in terms of overall survival.
Yet despite these encouraging successes, in general, very little is known about the basic immunological mechanisms involved in vaccine immunotherapy.
Gaining a better understanding of the mechanisms that govern the specific immune responses (i.e., cytotoxic T lymphocytes, CD4 T helper cells, T regulatory cells, cells of innate immunity, tumor escape mechanisms) elicited by each of the various vaccine platforms should be a concern of cancer vaccine clinical trials, along with clinical benefits.
This review focuses on current strategies employed by recent clinical trials of therapeutic cancer vaccines and analyzes them both clinically and immunologically.
American Psychological Association (APA)
Vergati, Matteo& Intrivici, Chiara& Huen, Ngar-Yee& Schlom, Jeffrey& Tsang, Kwong Y.. 2010. Strategies for Cancer Vaccine Development. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-483806
Modern Language Association (MLA)
Vergati, Matteo…[et al.]. Strategies for Cancer Vaccine Development. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-483806
American Medical Association (AMA)
Vergati, Matteo& Intrivici, Chiara& Huen, Ngar-Yee& Schlom, Jeffrey& Tsang, Kwong Y.. Strategies for Cancer Vaccine Development. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-483806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483806