Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics
Joint Authors
Gardner, Kristen N.
Ellingrod, Vicki L.
Johnson, Joshua W.
Burghardt, Kyle J.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Atypical antipsychotics have become a common therapeutic option in both schizophrenia and bipolar disorder.
However, these medications come with a high risk of metabolic side effects, particularly dyslipidemia and insulin resistance.
Therefore, identification of patients who are at increased risk for metabolic side effects is of great importance.
The genetics of fatty acid metabolism is one area of research that may help identify such patients.
Therefore, in this present study, we aimed to determine the effect of one commonly studied genetic polymorphism from both fatty acid desaturase 1 (FADS1) and FADS2 gene on a surrogate measure of insulin resistance and lipid levels in a metabolically high-risk population of patients largely exposed to atypical antipsychotics.
This study used a cross-sectional design, fasting blood draws, and genetic analysis to investigate associations between polymorphisms, haplotypes, and metabolic measures.
A total of 320 subjects with schizophrenia (n=226) or bipolar disorder (n=94) were included in this study.
The mean age of the population was 42.5 years and 45% were male.
A significant association between FADS1 and FADS2 haplotypes was found with insulin resistance while controlling for confounders.
Further investigation is required to replicate this finding.
American Psychological Association (APA)
Burghardt, Kyle J.& Gardner, Kristen N.& Johnson, Joshua W.& Ellingrod, Vicki L.. 2013. Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics. Cardiovascular Psychiatry and Neurology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-483849
Modern Language Association (MLA)
Burghardt, Kyle J.…[et al.]. Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics. Cardiovascular Psychiatry and Neurology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-483849
American Medical Association (AMA)
Burghardt, Kyle J.& Gardner, Kristen N.& Johnson, Joshua W.& Ellingrod, Vicki L.. Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics. Cardiovascular Psychiatry and Neurology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-483849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483849