Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca2+-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants
Joint Authors
Benzo, Zully
Abad, Cilia
Botana, Desirée
Piñero, Sandy
Marín, Reinaldo
Chiarello, Delia I.
Proverbio, Fulgencio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In the current study the possible relationship between the Ca2+/Mg2+ ratio of human syncytiotrophoblast plasma membranes and their lipid peroxidation and Ca2+-ATPase activity was determined.
Syncytiotrophoblast plasma membranes of placental explants cultured under hypoxia increased their lipid peroxidation and Ca2+ content, diminished their Ca2+-ATPase activity, and kept their Mg2+ content unchanged.
Membranes preincubated with different concentrations of Ca2+ increased their Ca2+ content without changes in their Mg2+ content.
There is a direct relationship between Ca2+ content and lipid peroxidation of the membranes, as well as an inverse relationship between their Ca2+ content and Ca2+-ATPase activity.
On the contrary, preincubation of membranes with different concentrations of Mg2+ showed a higher Mg2+ content without changing their lipid peroxidation and Ca2+-ATPase activity.
Explants cultured under hypoxia in the presence of 4 mM MgSO4 showed similar values of lipid peroxidation and Ca2+-ATPase activity of their membranes compared to those of explants cultured under normoxia.
Increased Ca2+ content of the membranes by interacting with negatively charged phospholipids could result in destabilizing effects of the membrane structure, exposing hydrocarbon chains of fatty acids to the action of free radicals.
Mg2+ might exert a stabilizing effect of the membranes, avoiding their exposure to free radicals.
American Psychological Association (APA)
Chiarello, Delia I.& Marín, Reinaldo& Proverbio, Fulgencio& Benzo, Zully& Piñero, Sandy& Botana, Desirée…[et al.]. 2014. Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca2+-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-483892
Modern Language Association (MLA)
Chiarello, Delia I.…[et al.]. Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca2+-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-483892
American Medical Association (AMA)
Chiarello, Delia I.& Marín, Reinaldo& Proverbio, Fulgencio& Benzo, Zully& Piñero, Sandy& Botana, Desirée…[et al.]. Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca2+-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-483892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483892