Bevacizumab Improves Quality of Life in Patients with Recurrent Glioblastoma
Joint Authors
Harsh, Griffith
Recht, Lawrence
Nagpal, Seema
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To quantify the benefits in survival and quality of life in patients receiving bevacizumab (BEV) for recurrent glioblastoma (GBM).
Methods.
This is a retrospective study of 40 adult patients with recurrent GBM treated between 2005 and 2009 at a single institution.
All patients had initial treatment with surgery, radiation, and concurrent temozolomide, then monthly temozolomide.
Over 250 charts were screened.
Sufficient data was available for 20 patients treated with BEV and 20 patients who did not receive BEV at the time of recurrence.
The independent living score (ILS), designed to reward long-term independent survival, was calculated for each patient.
Results.
The mean ILS was nearly double in the BEV group compared to the No-BEV group (15.0 versus 8.2, P=0.002, t-test).
Two months after initiation of therapy, the median steroid dose dropped by over 90% in patients treated with BEV, but doubled in the NoBEV group.
Median survival from the time of recurrence was significantly affected: 10.6 months in the BEV group versus 4.2 months (P<0.001, log rank survival) in the NoBEV group.
Conclusions.
BEV increases independent living and lengthens overall survival after GBM recurrence.
Reduction in steroid dose may contribute to prolonged independence.
American Psychological Association (APA)
Nagpal, Seema& Harsh, Griffith& Recht, Lawrence. 2011. Bevacizumab Improves Quality of Life in Patients with Recurrent Glioblastoma. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-484220
Modern Language Association (MLA)
Nagpal, Seema…[et al.]. Bevacizumab Improves Quality of Life in Patients with Recurrent Glioblastoma. Chemotherapy Research and Practice No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-484220
American Medical Association (AMA)
Nagpal, Seema& Harsh, Griffith& Recht, Lawrence. Bevacizumab Improves Quality of Life in Patients with Recurrent Glioblastoma. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-484220
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484220