Lipid Rafts : Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes
Joint Authors
Rushworth, Jo V.
Hooper, Nigel M.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Lipid rafts are membrane microdomains, enriched in cholesterol and sphingolipids, into which specific subsets of proteins and lipids partition, creating cell-signalling platforms that are vital for neuronal functions.
Lipid rafts play at least three crucial roles in Alzheimer's Disease (AD), namely, in promoting the generation of the amyloid-β (Aβ) peptide, facilitating its aggregation upon neuronal membranes to form toxic oligomers and hosting specific neuronal receptors through which the AD-related neurotoxicity and memory impairments of the Aβ oligomers are transduced.
Recent evidence suggests that Aβ oligomers may exert their deleterious effects through binding to, and causing the aberrant clustering of, lipid raft proteins including the cellular prion protein and glutamate receptors.
The formation of these pathogenic lipid raft-based platforms may be critical for the toxic signalling mechanisms that underlie synaptic dysfunction and neuropathology in AD.
American Psychological Association (APA)
Rushworth, Jo V.& Hooper, Nigel M.. 2010. Lipid Rafts : Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-484249
Modern Language Association (MLA)
Rushworth, Jo V.& Hooper, Nigel M.. Lipid Rafts : Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-484249
American Medical Association (AMA)
Rushworth, Jo V.& Hooper, Nigel M.. Lipid Rafts : Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-484249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484249