An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks
Joint Authors
Quong, Andrew A.
Gormley, Michael
Quong, Judy N.
Akella, Viswanadha U.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Identification of regulatory molecules in signaling pathways is critical for understanding cellular behavior.
Given the complexity of the transcriptional gene network, the relationship between molecular expression and phenotype is difficult to determine using reductionist experimental methods.
Computational models provide the means to characterize regulatory mechanisms and predict phenotype in the context of gene networks.
Integrating gene expression data with phenotypic data in transcriptional network models enables systematic identification of critical molecules in a biological network.
We developed an approach based on fuzzy logic to model cell budding in Saccharomyces cerevisiae using time series expression microarray data of the cell cycle.
Cell budding is a phenotype of viable cells undergoing division.
Predicted interactions between gene expression and phenotype reflected known biological relationships.
Dynamic simulation analysis reproduced the behavior of the yeast cell cycle and accurately identified genes and interactions which are essential for cell viability.
American Psychological Association (APA)
Gormley, Michael& Akella, Viswanadha U.& Quong, Judy N.& Quong, Andrew A.. 2011. An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks. Advances in Bioinformatics،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-484727
Modern Language Association (MLA)
Gormley, Michael…[et al.]. An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks. Advances in Bioinformatics No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-484727
American Medical Association (AMA)
Gormley, Michael& Akella, Viswanadha U.& Quong, Judy N.& Quong, Andrew A.. An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks. Advances in Bioinformatics. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-484727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484727