Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents : Implications for the Pathophysiology of Major Depressive Disorder
Joint Authors
Antonio Behr, Guilherme
Frey, Benicio N.
Fonseca Moreira, José Cláudio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Major depressive disorder (MDD) is a common mental disorder associated with a significant negative impact on quality of life, morbidity/mortality, and cognitive function.
Individuals who suffer with MDD display lower serum/plasmatic total antioxidant potentials and reduced brain GSH levels.
Also, F2-isoprostanes circulatory levels are increased in MDD subjects and are correlated with the severity of depressive symptoms.
Urinary excretion of 8-OHdG seems to be higher in patients with MDD compared to healthy controls.
Despite the fact that antidepressant drugs have been used for more than 50 years, their mechanism of action is still not fully understood.
This paper examines preclinical (in vitro and animal model) and clinical literature on oxidative/antioxidant effects associated with antidepressant agents and discusses their potential antioxidant-related effects in the treatment of MDD.
Substantial data support that MDD seems to be accompanied by elevated levels of oxidative stress and that antidepressant treatments may reduce oxidative stress.
These studies suggest that augmentation of antioxidant defences may be one of the mechanisms underlying the neuroprotective effects of antidepressants in the treatment of MDD.
American Psychological Association (APA)
Antonio Behr, Guilherme& Fonseca Moreira, José Cláudio& Frey, Benicio N.. 2012. Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents : Implications for the Pathophysiology of Major Depressive Disorder. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-484840
Modern Language Association (MLA)
Antonio Behr, Guilherme…[et al.]. Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents : Implications for the Pathophysiology of Major Depressive Disorder. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-484840
American Medical Association (AMA)
Antonio Behr, Guilherme& Fonseca Moreira, José Cláudio& Frey, Benicio N.. Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents : Implications for the Pathophysiology of Major Depressive Disorder. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-484840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-484840