Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma
Joint Authors
Cheng, Weihua
Choi, Chul-Hee
Chen, Kejian
Floyd, Robert A.
Kopke, Richard D.
Du, Xiaoping
Source
International Journal of Otolaryngology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-25
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
Inhibition of inflammation and free radical formation in the cochlea may be involved in antioxidant treatment in acute acoustic trauma.
Procedure.
Chinchilla were exposed to 105 dB sound pressure level octave band noise for 6 hours.
One group of chinchilla was treated with antioxidants after noise exposure.
Auditory brainstem responses, outer hair cell counts, and immunohistochemical analyses of biomarkers in the cochlea were conducted.
Results.
The antioxidant treatment significantly reduced hearing threshold shifts, outer hair cell loss, numbers of CD45+ cells, as well as 4-hydroxy-2-nonenal and nitrotyrosine formation in the cochlea.
Conclusion.
Antioxidant treatment may provide protection to sensory cells by inhibiting formation of reactive oxygen and nitrogen products and migration of mononuclear phagocytes in the cochlea.
The present study provides further evidence of effectiveness of antioxidant treatment in reducing permanent hearing loss.
American Psychological Association (APA)
Du, Xiaoping& Choi, Chul-Hee& Chen, Kejian& Cheng, Weihua& Floyd, Robert A.& Kopke, Richard D.. 2011. Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma. International Journal of Otolaryngology،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-485078
Modern Language Association (MLA)
Du, Xiaoping…[et al.]. Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma. International Journal of Otolaryngology No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-485078
American Medical Association (AMA)
Du, Xiaoping& Choi, Chul-Hee& Chen, Kejian& Cheng, Weihua& Floyd, Robert A.& Kopke, Richard D.. Reduced Formation of Oxidative Stress Biomarkers and Migration of Mononuclear Phagocytes in the Cochleae of Chinchilla after Antioxidant Treatment in Acute Acoustic Trauma. International Journal of Otolaryngology. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-485078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485078