PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1PGE2 Pathway in dbdb Mice
Joint Authors
Sun, Ying
Yang, Baoxue
Yang, Tianxin
Liu, Gang
Jia, Zhanjun
Zhou, Li
Liu, Mi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Evidence had shown the detrimental effect of prostaglandin (PG) E2 in diabetic nephropathy (DN) of STZ-induced type-1 diabetes but its role in the development of DN of type-2 diabetes remains uncertain.
The present study was undertaken to investigate the regulation of PGE2 synthetic pathway and the interaction between peroxisome proliferator-activated receptor (PPAR)γ and PGE2 synthesis in the kidneys of db/db mice.
Strikingly, urinary PGE2 was remarkably elevated in db/db mice paralleled with the increased protein expressions of COX-2 and mPGES-1.
In contrast, the protein expressions of COX-1, mPGES-2, cPGES, and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) were not altered.
Following 1-week rosiglitazone (Rosi) therapy, urinary PGE2, but not other prostanoids, was reduced by 57% in parallel with significant reduction of mPGES-1 protein and EP4 mRNA expressions.
By immunohistochemistry, mPGES-1 was significantly induced in the glomeruli of db/db mice, which was almost entirely abolished by Rosi.
In line with the reduction of glomerular mPGES-1, the glomerular injury score showed a tendency of improvement after 1 week of Rosi therapy.
Collectively, the present study demonstrated an inhibitory effect of PPARγ activation on renal mPGES-1/PGE2/EP4 pathway in type-2 diabetes and suggested that mPGES-1 may potentially serve as a therapeutic target for treating type-2 diabetes-associated DN.
American Psychological Association (APA)
Sun, Ying& Jia, Zhanjun& Liu, Gang& Zhou, Li& Liu, Mi& Yang, Baoxue…[et al.]. 2013. PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1PGE2 Pathway in dbdb Mice. PPAR Research،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485106
Modern Language Association (MLA)
Sun, Ying…[et al.]. PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1PGE2 Pathway in dbdb Mice. PPAR Research No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-485106
American Medical Association (AMA)
Sun, Ying& Jia, Zhanjun& Liu, Gang& Zhou, Li& Liu, Mi& Yang, Baoxue…[et al.]. PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1PGE2 Pathway in dbdb Mice. PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-485106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485106