Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain
Joint Authors
Latourelle, Jeanne C.
Hendricks, Audrey E.
Hadzi, Tiffany C.
Moser, Carlee
DeStefano, Anita L.
Myers, Richard H.
Dumitriu, Alexandra
Williamson, Sally L.
Wilk, Jemma B.
Pacheco, Christopher D.
Source
International Journal of Distributed Sensor Networks
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Telecommunications Engineering
Information Technology and Computer Science
Abstract EN
Duplications and triplications of the α-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk.
However, past SNCA expression studies in brain tissue report inconsistent results.
We examined expression of the full-length SNCA transcript (140 amino acid protein isoform), as well as total SNCA mRNA levels in 165 frontal cortex samples (101 PD, 64 control) using quantitative real-time polymerase chain reaction.
Additionally, we evaluated the relationship of eight SNPs in both 5′ and 3′ regions of SNCA with the gene expression levels.
The association between postmortem interval (PMI) and SNCA expression was different for PD and control samples: SNCA expression decreased with increasing PMI in cases, while staying relatively constant in controls.
For short PMI, SNCA expression was increased in PD relative to control samples, whereas for long PMI, SNCA expression in PD was decreased relative to control samples.
American Psychological Association (APA)
Dumitriu, Alexandra& Moser, Carlee& Hadzi, Tiffany C.& Williamson, Sally L.& Pacheco, Christopher D.& Hendricks, Audrey E.…[et al.]. 2012. Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain. International Journal of Distributed Sensor Networks،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485212
Modern Language Association (MLA)
Dumitriu, Alexandra…[et al.]. Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain. International Journal of Distributed Sensor Networks No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-485212
American Medical Association (AMA)
Dumitriu, Alexandra& Moser, Carlee& Hadzi, Tiffany C.& Williamson, Sally L.& Pacheco, Christopher D.& Hendricks, Audrey E.…[et al.]. Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain. International Journal of Distributed Sensor Networks. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485212