An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice
Joint Authors
Di Pierro, Francesco
Rossoni, Giuseppe
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity.
The aim of this study was to evaluate the protective role of DDM-GSH, a mixture of L-cysteine, L-methionine, and L-serine in a weight ratio of 2 : 1 : 1, in comparison to N-acetylcysteine (NAC), against acetaminophen- (APAP-) induced hepatotoxicity in mice.
Toxicity was induced in mice by the intraperitoneal (ip) administration of low dose (2 mmol/kg) or high dose (8 mmol/kg) of APAP.
DDM-GSH (0.4 to 1.6 mmol/kg) was given ip to mice 1 h before the APAP administration.
The same was done with NAC (0.9 to 3.6 mmol/kg), the standard antidote of APAP toxicity.
Mice were sacrificed 8 h after the APAP injection to determine liver weight, serum alanine aminotransferase (ALT), and total glutathione (GSH) depletion and malondialdehyde (MDA) accumulation in liver tissues.
DDM-GSH improved mouse survival rates better than NAC against a high dose of APAP.
Moreover, DDM-GSH significantly reduced in a dose-dependent manner not only APAP-induced increases of ALT but also APAP-induced hepatic GSH depletion and MDA accumulation.
Our results suggest that DDM-GSH may be more potent than NAC in protecting the liver from APAP-induced liver injury.
American Psychological Association (APA)
Di Pierro, Francesco& Rossoni, Giuseppe. 2013. An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice. Journal of Amino Acids،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-485346
Modern Language Association (MLA)
Di Pierro, Francesco& Rossoni, Giuseppe. An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice. Journal of Amino Acids No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-485346
American Medical Association (AMA)
Di Pierro, Francesco& Rossoni, Giuseppe. An Amino Acids Mixture Improves the Hepatotoxicity Induced by Acetaminophen in Mice. Journal of Amino Acids. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-485346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485346