MicroRNA-224 Suppresses Colorectal Cancer Cell Migration by Targeting Cdc42
Joint Authors
Chen, William Tzu-Liang
Cheng, Ya-Wen
Cheng, Chao-Wen
Wu, Yu-Hua
Hsu, Han-Lin
Ke, Tao-Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The metastatic spread of tumor cells is the major risk factor affecting the clinical prognosis of colorectal cancer (CRC) patients.
The metastatic phenotype can be modulated by dysregulating the synthesis of different structural and functional proteins of tumor cells.
Micro(mi)RNAs are noncoding RNAs that recognize their cognate messenger (m)RNA targets by sequence-specific interactions with the 3′ untranslated region and are involved in the multistep process of CRC development.
The objective of this study was to investigate the expression and biological roles of miR-224 in CRC.
The miR-224 expression level was assessed by a quantitative real-time PCR in 79 CRC and 18 nontumor tissues.
Expression levels of miR-224 in CRC tissues were significantly lower than those in nontumor tissues.
Its expression level was associated with the mutation status of the APC gene.
Ectopic expression of miR-224 suppressed the migratory ability of CRC cell line, but cell proliferation was less affected.
Increased miR-224 diminished Cdc42 and SMAD4 expressions at both the protein and mRNA levels and inhibited the formation of actin filaments.
Overall, this study indicated a role of miR-224 in negatively regulating CRC cell migration.
The expression level of miR-224 may be a useful predictive biomarker for CRC progression.
American Psychological Association (APA)
Ke, Tao-Wei& Hsu, Han-Lin& Wu, Yu-Hua& Chen, William Tzu-Liang& Cheng, Ya-Wen& Cheng, Chao-Wen. 2014. MicroRNA-224 Suppresses Colorectal Cancer Cell Migration by Targeting Cdc42. Disease Markers،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-485457
Modern Language Association (MLA)
Ke, Tao-Wei…[et al.]. MicroRNA-224 Suppresses Colorectal Cancer Cell Migration by Targeting Cdc42. Disease Markers No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-485457
American Medical Association (AMA)
Ke, Tao-Wei& Hsu, Han-Lin& Wu, Yu-Hua& Chen, William Tzu-Liang& Cheng, Ya-Wen& Cheng, Chao-Wen. MicroRNA-224 Suppresses Colorectal Cancer Cell Migration by Targeting Cdc42. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-485457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485457