Serum Levels of Resistin, Adiponectin, and Apelin in Gastroesophageal Cancer Patients
Joint Authors
Grabowski, Krzysztof
Markocka-Mączka, Krystyna
Szelachowski, Piotr
Diakowska, Dorota
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the study was the investigation of relationship between cachexia syndrome and serum resistin, adiponectin, and apelin in patients with gastroesophageal cancer (GEC).
Material and Methods.
Adipocytokines concentrations were measured in sera of 85 GEC patients and 60 healthy controls.
They were also evaluated in tumor tissue and appropriate normal mucosa of 38 operated cancer patients.
Results.
Resistin and apelin concentrations were significantly higher in GEC patients than in the controls.
The highest resistin levels were found in cachectic patients and in patients with distant metastasis.
Serum adiponectin significantly decreased in GEC patients with regional and distant metastasis.
Serum apelin was significantly higher in cachectic patients than in the controls.
Apelin was positively correlated with hsCRP level.
Resistin and apelin levels increased significantly in tumor tissues.
Weak positive correlations between adipocytokines levels in serum and in tumor tissue were observed.
Conclusions.
Resistin is associated with cachexia and metastasis processes of GEC.
Reduction of serum adiponectin reflects adipose tissue wasting in relation to GEC progression.
Correlation of apelin with hsCRP can reflect a presumable role of apelin in systemic inflammatory response in esophageal and gastric cancer.
American Psychological Association (APA)
Diakowska, Dorota& Markocka-Mączka, Krystyna& Szelachowski, Piotr& Grabowski, Krzysztof. 2014. Serum Levels of Resistin, Adiponectin, and Apelin in Gastroesophageal Cancer Patients. Disease Markers،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485702
Modern Language Association (MLA)
Diakowska, Dorota…[et al.]. Serum Levels of Resistin, Adiponectin, and Apelin in Gastroesophageal Cancer Patients. Disease Markers No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-485702
American Medical Association (AMA)
Diakowska, Dorota& Markocka-Mączka, Krystyna& Szelachowski, Piotr& Grabowski, Krzysztof. Serum Levels of Resistin, Adiponectin, and Apelin in Gastroesophageal Cancer Patients. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-485702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485702