Serotonin Receptor 2AC Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model
Joint Authors
Zhang, Rui-Xin
Ren, Ke
Zhang, Yu
Berman, Brian
Li, Aihui
Xin, Jiajia
Lao, Lixing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Osteoarthritis currently has no cure.
Acupuncture can benefit patients with knee osteoarthritis by providing pain relief, improving joint function and serving as an effective complement to standard care.
However, the underlying mechanisms of its effects are still not completely understood.
The present study, an investigation of the effectiveness and mechanisms of electroacupuncture (EA) in attenuating osteoarthritis pain in a rat model, is focused on the involvement of 5-hydroxytryptamine 2A/C (5-HT2A/C) receptors, which play an important role in pain modulation at the spinal level.
Osteoarthritis was induced under isoflurane anesthesia by a single intraarticular injection of monosodium iodoacetate (3 mg/50 μL/rat) into one hind leg of each rat.
EA was given at acupoints GB 30 and ST 36 on days 1–4 after the injection.
Vehicle or ketanserin, a 5-HT2A/C receptor antagonist, was given intraperitoneally (1 mg kg−1) or intrathecally (5 μg or 10 μg/10 μL), 30 min before each EA treatment.
Assessment of weight-bearing difference between injected and uninjected hind legs was done on days 0, 1–4 and 7.
Fos /serotonin and serotonin/Fluorogold double labeling were performed to determine EA activation of serotonergic neurons in the nucleus raphe magnus (NRM) that project to spinal cord.
The results showed that EA significantly decreases weight-bearing difference compared to sham EA.
Ketanserin pretreatment blocked the analgesic effect of EA but did not influence weight bearing in sham EA control rats.
EA also activated serotonergic NRM neurons that project to the spinal cord.
These data show that EA inhibits osteoarthritis-induced pain by enhancing spinal 5-HT2A/2C receptor activity.
American Psychological Association (APA)
Li, Aihui& Zhang, Yu& Lao, Lixing& Xin, Jiajia& Ren, Ke& Berman, Brian…[et al.]. 2011. Serotonin Receptor 2AC Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485703
Modern Language Association (MLA)
Li, Aihui…[et al.]. Serotonin Receptor 2AC Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-485703
American Medical Association (AMA)
Li, Aihui& Zhang, Yu& Lao, Lixing& Xin, Jiajia& Ren, Ke& Berman, Brian…[et al.]. Serotonin Receptor 2AC Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485703