Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction
Joint Authors
Masters, Colin L.
Cherny, Robert A.
McLean, Catriona
Hare, Dominic J.
Fowler, Christopher J.
Roberts, Blaine R.
Rembach, Alan
Bush, Ashley I.
Lind, Monica
Source
International Journal of Differential Equations
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society.
The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeostasis of these essential elements, which can impart profound effects on cell viability and neuronal function.
We tested the hypothesis that there is a systemic perturbation in Cu compartmentalization in AD, within the brain as well as in the periphery, specifically within erythrocytes.
Our results showed that the previously reported decrease in Cu within the human frontal cortex was confined to the soluble (P<0.05) and total homogenate (P<0.05) fractions.
No differences were observed in Cu concentration in erythrocytes.
Our data indicate that there is a brain specific alteration in Cu levels in AD localized to the soluble extracted material, which is not reflected in erythrocytes.
Further studies using metalloproteomics approaches will be able to elucidate the metabolic mechanism(s) that results in the decreased brain Cu levels during the progression of AD.
American Psychological Association (APA)
Rembach, Alan& Hare, Dominic J.& Lind, Monica& Fowler, Christopher J.& Cherny, Robert A.& McLean, Catriona…[et al.]. 2013. Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction. International Journal of Differential Equations،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485947
Modern Language Association (MLA)
Rembach, Alan…[et al.]. Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction. International Journal of Differential Equations No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-485947
American Medical Association (AMA)
Rembach, Alan& Hare, Dominic J.& Lind, Monica& Fowler, Christopher J.& Cherny, Robert A.& McLean, Catriona…[et al.]. Decreased Copper in Alzheimer’s Disease Brain Is Predominantly in the Soluble Extractable Fraction. International Journal of Differential Equations. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485947