Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats
Joint Authors
Ding, Shu-hua
Shao, Yan
Yang, Xue-wen
Yu, Hai-tao
Xu, Xin-rong
Hang, Li
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Choroidal neovascularization (CNV) is characterized by abnormal blood vessels growing from the choroid.
Current remedies for CNV have not shown favorable therapeutic efficacy.
It is urgent to identify and develop more safe and potent anti-CNV agents via multiple technologies.
We previously showed that the natural product naringenin attenuated CNV.
However, naringenin has poor water solubility and low bioavailability.
Here, we prepared the β-cyclodextrin (β-CD) complex of naringenin and characterized it using infrared spectra and X-ray diffraction analyses.
Determination of content and solubility in the complex showed that naringenin accounted for 20.53% in the complex and its solubility was increased by more than 10-fold.
Using a laser-induced CNV model in rats we demonstrated that naringenin/β-CD complex more significantly reduced CNV area than naringenin alone in rats.
Furthermore, naringenin and its β-CD complex significantly inhibited the mRNA and protein expression of VEGF, COX-2, PI3K, p38MAPK, MMP-2, and MMP-9 in retina and choroid tissues.
Naringenin/β-CD complex showed more significant inhibitory effect on VEGF and COX-2 expression than naringenin.
These results collectively indicated that naringenin/β-CD complex could be a promising therapeutic option for CNV and that the beneficial effects could be linked to the anti-inflammatory properties of naringenin.
American Psychological Association (APA)
Xu, Xin-rong& Yu, Hai-tao& Hang, Li& Shao, Yan& Ding, Shu-hua& Yang, Xue-wen. 2014. Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-485961
Modern Language Association (MLA)
Xu, Xin-rong…[et al.]. Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-485961
American Medical Association (AMA)
Xu, Xin-rong& Yu, Hai-tao& Hang, Li& Shao, Yan& Ding, Shu-hua& Yang, Xue-wen. Preparation of Naringeninβ-Cyclodextrin Complex and Its More Potent Alleviative Effect on Choroidal Neovascularization in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-485961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485961